In April 1999, roughly ten years after his battle against DIO, Jotaro Kujo travels to the town of Morioh to look for a boy named Josuke Higashikata. After first running into a timid boy named Koichi Hirose, Jotaro comes across Josuke as he fights with some upperclassmen who injured a turtle and insulted his hairstyle, discovering that he possesses a Stand that has the power to heal wounds. Jotaro then introduces himself, revealing to Josuke that he is the illegitimate son of his grandfather, Joseph Joestar, thus technically making him Jotaro's uncle. When Jotaro inadvertently insults his hairstyle, Josuke brings out his Stand Crazy Diamond against Jotaro, who narrowly avoids serious injury thanks to his Star Platinum's ability to temporarily stop time. Afterwards, Jotaro warns Josuke about a dangerous Stand user and serial killer named Anjuro "Angelo" Katagiri who is hiding out in town. The next day, as Josuke encounters a convenience store robbery the next day, he steps in after his hair is insulted again and uses Crazy Diamond to save the store clerk and implant the burglar's knife inside the man's own body. Just then, Josuke discovers that the burglar was being possessed by Angelo's Stand, Aqua Necklace, after which Angelo threatens to kill Jotaro and his family.

Angelo sneaks Aqua Necklace into the Higashikata residence in the hope of killing Josuke's mother Tomoko, but Josuke manages to catch it before it can kill her and trap it inside a bottle. When Josuke's grandfather Ryohei comes home, however, Angelo, remembering that Ryohei was the one who put him in jail, tricks him into setting Aqua Necklace free and kills him. Josuke uses Crazy Diamond's ability to heal Ryohei's wounds but is saddened to discover that his power can't bring back those who have already died. As Josuke and Jotaro spend the next few days thinking of a plan to stop Angelo, they become surrounded after a rain storm floods the house, allowing Aqua Necklace to move freely through puddles and mist. Angelo attempts to kill Josuke by sending Aqua Necklace through a humidifier into its mouth, but Josuke traps it in a rubber glove he had swallowed earlier. Upon finding Angelo's physical body, Josuke takes revenge for his grandfather by trapping Angelo in a rock.

Angelo reveals to Josuke and Jotaro that he received his Stand ability from a man in a school uniform who shot him with a mysterious bow and arrow, mentioning Dio's name. Angelo attempts to use this discussion to distract the two and attack a nearby child with Aqua Necklace, but Josuke further merges him with the rock, permanently transforming him into the "Angelo Stone". Realizing that the bow and arrow may be what originally gave Dio his Stand, Jotaro decides to stay in Morioh to investigate. The next day, as Josuke and Koichi pass by what should be an abandoned house near Josuke's house, Koichi is attacked the Nijimura brothers, Okuyasu and Keicho, the latter of whom shoots an arrow through Koichi's neck. Before Josuke can rush to Koichi's aid, he is confronted by Okuyasu and his Stand The Hand, which can erase anything its right hand touches and instantly close the gap. Josuke uses this to his advantage by tricking Okuyasu into removing the space between him and some potted plants, which launch towards him and knock him out, allowing Josuke to move on inside the house.